Effect of pioglitazone therapy on high sensitive C-reactive protein and lipid profile in diabetic patients with renal transplantation; a randomize clinical trial


Authors:

Hamidreza Karimi-Sari 1, Rana Arashnia 2, Kobra Roohi-Gilani 2, Ali Bahramifar 3 1- Students’ Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran 2- Urology and Nephrology Research Center, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences. Tehran, Iran 3- Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Correspondence:

dr.karimih@yahoo.com

Introduction: Inflammation has a major role in disease lead to renal failure and diabetes mellitus, controlling inflammation in diabetic kidney receivers could decrease morbidity and mortality.

Objectives: This study designed for evaluating the efficacy of pioglitazone on C-reactive protein and lipid profile in diabetic kidney transplant receivers.

Patients and Methods: In this double blinded clinical trial, 58 diabetic renal transplant receivers, in first month after transplantation, randomized to two groups; receiving insulin and pioglitazone (15mg tablet daily, group A); and insulin and placebo (group B). Blood pressure, weight, BMI and laboratory data compared in before and after 4-month treatment in two groups by SPSS v.21 software.

Results: Fifty eight patients with mean age of 44.15 ± 2 years included. There were no significant difference between groups in demographic data and other baseline measured variables (P>0.05) .The mean weigh and BMI was slightly increased in group A and decreased in group B. The mean hs-CRP was decreased 4.82 mg/dL in group A and 1.93 mg/dL in group B (P=0.007). The mean total serum cholesterol was significantly decreased 34 mg/dL in group A and 18.07 mg/dL in group B (P=0.027). The mean serum HDL was significantly increased 13.31 mg/dL in group A and 5.89 mg/dl in group B (P<0.001) .

Conclusions: Pioglitazone seems to be a safe drug for reducing serum lipids and CRP in kidney transplant receivers with diabetes mellitus in short term. Long term effect of this drug could be evaluated in future studies.

Keywords: Pioglitazone, C-reactive protein, Cholesterol, Diabetes mellitus, Kidney transplantation