Antibiotic lock therapy for treatment of catheter-related bloodstream infections in hemodialysis patients


ali karimi rozveh PhD Candidate in Nursing Education, Kashan University of Medical Sciences, Kashan, IR Iran Mohsen Adib-Hajbaghery Ph.D in Nursing Education, Kashan University of Medical Sciences, Kashan, IR Iran



Central venous catheters as vascular access for dialysis patients often are used.But as catheter-related infectious complications remains a major problem in clinical.The concept of antibiotic lock technique was developed in the late 1980s as a derivation of the heparin lock technique.This method involves injecting a diluted solution of antibiotics for the prevention and treatment of catheter infection is catheters.


Researchers used plumbed, Proquest, , Science Directand SID databases. Articles published in 2010 to 2015 were studied. ‘Antibiotic lock therapy, catheter, hemodialysis’ was used as a keyword to find relevant articles. 10 articles related to Antibiotic lock therapy were included in the present study.


studies show that the using of 3 to 4 ml of antibiotic solution is useful to the prevention and treatment of intravascular catheter-infection. in order to this vancomycin solution mg / ml5, gentamicin mg / ml1, amikacin mg / ml2, ciprofloxacin mg / ml2 or other antibiotics could be used. This method can be used in conjunction with heparinize the catheters. Also the use of this method in conjunction with systemic antibiotics leads to more effective treatment of catheter infections. Consulting with a nephrologist or ID specialist is necessary to prevent overdose in hemodialysis patients. In case of continues fever despite antibiotics therapy catheter should be removed and 4 to 6 weeks of antibiotic therapy should be done because of probable endocarditis, osteomyelitis or septic thrombophlebitis.


Studies have shown that antibiotic lock solutions probably decrease catheter-related blood stream infection in hemodialysis patients.and Catheters survival duration are increased.